Are genetics a minor contributor to common chronic diseases and longevity?

“really 80% of heart disease is preventable. There's only 20% that's some genetic component to it, some congenital anomalies or LP little a.”

“there's no more than 10% of how long you live that's genetically driven. Like the best studies put this at around 7%. 7% of, of longevity is genetically inherited maybe, and then about 90% is not.”

“Because it's very clear that there's no more than 10% of how long you live that's genetically driven. Like the best studies put this at around 7%. 7% of longevity is genetically inherited maybe, and then about 90% is not.”

“if the Human Genome Project and the search for causal genes for common chronic diseases had been an RCT, it would have failed its primary endpoint. I think if we're real about this, the, the hypothesis was wrong.”

“there was no gene that really Came out, even in several million people, that explain these diseases, other than a, a general tendency to get any type of brain disease.”

“when we looked at brain diseases, there was very little similarity in the twins. So the genetic component was always quite small, apart from a few diseases. Most of them were really low level, what we call heritability.”

“Only around 3% of the disease cases right now were driven through those genetic mutations.”

“95% of them could have been prevented because this is not a disease of genetics, it's a disease of lifestyle.”

“It's pretty useless information because what happens is, is that family history is true because we eat, live, and think like our family members did.”

“heart disease is 100% preventable. It's not genetic. People don't have the genetic risk for heart attacks and strokes. People have perfect genes.”

“family history is not a genetic problem, our genetics are perfect”

“These things run in families, but they are not genetic. Because if I can get you to subscribe to the fact that you have a genetically inherited disease, I can easily get you to subscribe to a lifetime of medication.”

“The vast majority of Alzheimer's disease is what we would call late-onset Alzheimer's disease ... it's much more related to lifestyle and the environment than, say, that, that kind of early onset monogenic, Alzheimer's disease.”

“for most of those conditions, that gene does not exist. ... we do not pass disease from generation to generation.”

“the majority of disease is genetically inherited. That is patently false.”

“That explains why it's increasing so rapidly. If it suddenly started to increase so rapidly, that does not speak to a genetic issue. Our genes aren't changing.”

“Only about 5 to 10% of cancers are genetic. The rest is environmental, and that has a lot to do with your epigenetics.”

“as the polygenic risk scores come into, we do them early in life, it can sort of predict who is going to make it to 80 and never have a heart attack and who is not, because they're looking at a multitude of genetic things that you are never looking at one at a time in an individual patient.”

“both my parents have hypertension, and therefore I understand that despite all of the things that I do to have low blood pressure, it won't be surprising to me at some point if my genes overcome my lifestyle, and at some point I'll need to take medication.”

“when people realize it is genetics, there's nothing they can do about it other than they're doing already doing great lifestyle and so forth. That becomes, I think, part of the motivation to get them to do something about it.”

“heart disease is 100% preventable. It's not genetic. People don't have the genetic risk for heart attacks and strokes. People have perfect genes.”

“if the Human Genome Project and the search for causal genes for common chronic diseases had been an RCT, it would have failed its primary endpoint. I think if we're real about this, the, the hypothesis was wrong.”

“there was no gene that really Came out, even in several million people, that explain these diseases, other than a, a general tendency to get any type of brain disease.”

“That explains why it's increasing so rapidly. If it suddenly started to increase so rapidly, that does not speak to a genetic issue. Our genes aren't changing.”

“95% of them could have been prevented because this is not a disease of genetics, it's a disease of lifestyle.”

“the majority of disease is genetically inherited. That is patently false.”

“family history is not a genetic problem, our genetics are perfect”

“when we looked at brain diseases, there was very little similarity in the twins. So the genetic component was always quite small, apart from a few diseases. Most of them were really low level, what we call heritability.”

“It's pretty useless information because what happens is, is that family history is true because we eat, live, and think like our family members did.”

“These things run in families, but they are not genetic. Because if I can get you to subscribe to the fact that you have a genetically inherited disease, I can easily get you to subscribe to a lifetime of medication.”

“for most of those conditions, that gene does not exist. ... we do not pass disease from generation to generation.”

“when people realize it is genetics, there's nothing they can do about it other than they're doing already doing great lifestyle and so forth. That becomes, I think, part of the motivation to get them to do something about it.”