Does deliberately reducing mTOR activity through drugs or diet improve human healthspan or longevity?

“if we're consuming animal protein, or really any type of protein, could be plant protein as well, from the moment we wake up to the moment we go to bed. So if we're consuming protein all day long, and it's really long feeding window, We are overdriving pathways like the mTOR pathway that increases cell reproduction, and that increased cell”

“when mTOR is chronically elevated, it causes too much cell reproduction. It stops autophagy, and we get an overgrowth of cells with damaged proteins, senescent cells that aren't functioning well, and that accelerates the aging process, creates something called inflammaging”

“They are getting a lot of autophagy, but they're Also losing muscle mass. We want to do it in such a way that optimizes muscle mass, but also allows us to get rid of the damaged proteins through that process of autophagy, so we can really age successfully and thrive in life.”

“So really the key to longevity is not just suppressing mTOR, but it's cycling between proper amounts of mTOR and proper amounts of autophagy.”

“While we're fasting, we can use caffeine, for example, to stimulate or to, to further suppress mTOR. We can, you know, ideally, obviously fasting, you're using caffeine, doing it in the morning, not at night. And then we can also use some of these different polyphenols, these different herbs, right? We can do, whether it's green tea, or we can”

“mTOR is a master regulator of metabolism. It needs to be balanced with what we call autophagy, which is signaled by the AMPK pathway.”

“Ketogenic diet, fasting mimicking, actually fasting or fasting mimicking diets like the ketogenic diet, it's, it's lowering these pro-growth pathways like mTOR to increasing things like autophagy, which is cellular recycling, increasing mitophagy, mitochondrial autophagy.”

“These compounds The mTOR pathway, and they activate autophagy. They activate that AMPK path, means your body goes into cellular cleanup.”

“I think the effect size is going to be modest, is it just as it has been preclinically?”

“I think it probably will. It's highly conserved biology across evolution, so I, I, I think so.”

“I currently am using a product very first thing after I cleanse called ReQ. This is a brand new thing. I, I don't even have much evidence. I don't, I don't have any of the white papers yet, but the way they market themselves is as a, a skin longevity topical, and it works somehow on the mTOR pathway, kind”

“the whole premise that mTOR suppression is going to help with longevity, they've never worked in a nursing home. mTOR is necessary, this idea that we're going to suppress this one pathway, and that that is what's going to make us live longer, is foolish. It is the same pathway that is stimulated with resistance training. By default, if you”

“when you chronically suppress mTOR, which again, there's a ton of different, a ton of problems with even the framework of this, is you also affect glucose. You become glucose intolerant. You change your lipid profile. There's all these whole hosts of other problems with it. So it's not just muscle. Insulin resistance, weakened immune system.”

“They are getting a lot of autophagy, but they're Also losing muscle mass. We want to do it in such a way that optimizes muscle mass, but also allows us to get rid of the damaged proteins through that process of autophagy, so we can really age successfully and thrive in life.”

“if we're consuming animal protein, or really any type of protein, could be plant protein as well, from the moment we wake up to the moment we go to bed. So if we're consuming protein all day long, and it's really long feeding window, We are overdriving pathways like the mTOR pathway that increases cell reproduction, and that increased cell”

“I think it probably will. It's highly conserved biology across evolution, so I, I, I think so.”

“So really the key to longevity is not just suppressing mTOR, but it's cycling between proper amounts of mTOR and proper amounts of autophagy.”

“when mTOR is chronically elevated, it causes too much cell reproduction. It stops autophagy, and we get an overgrowth of cells with damaged proteins, senescent cells that aren't functioning well, and that accelerates the aging process, creates something called inflammaging”

“the whole premise that mTOR suppression is going to help with longevity, they've never worked in a nursing home. mTOR is necessary, this idea that we're going to suppress this one pathway, and that that is what's going to make us live longer, is foolish. It is the same pathway that is stimulated with resistance training. By default, if you”

“when you chronically suppress mTOR, which again, there's a ton of different, a ton of problems with even the framework of this, is you also affect glucose. You become glucose intolerant. You change your lipid profile. There's all these whole hosts of other problems with it. So it's not just muscle. Insulin resistance, weakened immune system.”