Do GLP-1 weight-loss medications inherently lead to clinically significant long-term loss of muscle mass and strength for most users?

“We don't know, it's like if you're on Ozempic for a while, you lose weight and you get off of it, you know, you start to gain your weight back. Is, is it, is, is there some transition that like makes it your, that, that actually poses a health threat to you? there's like some evidence of muscle loss.”

“If she's lost weight now and then two years later wants to get off the drug, like 70% of people do, she will, her fat mass will come right back, but her lean mass may never come back. That muscle and bone may be gone for good.”

“when you lose weight, about a third of the weight you lose would be lean mass, right? So most muscle, right? Maybe some bone, et cetera. And the problem is when you cycle on and off, right? So say you come off of it and you put your weight back on, you're not putting the lean mass back on, okay?”

“I think that muscle loss, honestly, is one of the bigger ones, right? And it might just be subtle, like ozempic face, ozempic butt, right? You're losing some muscle in places where it's noticeable. Other people actually truly develop sarcopenia, I think, right? Where you have significant loss of muscle.”

“typically speaking about 50% of the weight that someone loses is fat and 50% is muscle. And, you know, so that's how sometimes people can end up getting quite frail, even though they've lost a considerable amount of weight.”

“with those medications, you're actually losing muscle mass.”

“I was skeptical until. I started following Dr. Jenna Siwak and Dr. Rocio Salas-Whalen on social and looking at the medical research journal articles they were presenting and then pulling them myself and reading them myself and realizing, wait a minute, I am allowing my own bias to stand in the way of what is, what could be potentially best”

“I started following Dr. Jenna Siwak and Dr. Rocio Salas-Whalen on social and looking at the medical research journal articles they were presenting and then pulling them myself and reading them myself and realizing, wait a minute, I am allowing my own bias to stand in the way of what is, what could be potentially best for a patient”

“The GLP-1 is simply a tool in the toolkit. There are multiple tools in the toolkit, adequate resistance training, adequate cardio, you know, exercising your body, lowering your stress, focusing on your sleep, doing all the things that are going to make a healthier body and help these medications help you.”

“We do in our clinic, and we manage nutrition and resistance training and lower dosing. Of these medications, it doesn't have to be very high doses.”

“They track in line with when an individual Loses weight, we see it's the same percentage. It's not something magical, but the problem is if individuals are abusing GLP-1s, not training, seeing the celebrity sphere become very skinny, sarcopenic, I believe that we're going to have an epidemic of sarcopenia that we defined as an aging change in muscle accelerated”

“The data, I believe, that is coming out and will continue to come out improves muscle quality, lowering the fat within the muscle.”

“everyone wants to know about like the sunken face or the flat butt. How do you prevent that on GLP-1? So we talked a little bit about that. ... you got to really make sure you're eating the protein. ... And you're, you're doing the strength training. Non-negotiable.”

“the GPS protocol, which is GLP-1 protein strength training. They have to go together.”

“The GLP-1 is simply a tool in the toolkit. There are multiple tools in the toolkit, adequate resistance training, adequate cardio, you know, exercising your body, lowering your stress, focusing on your sleep, doing all the things that are going to make a healthier body and help these medications help you.”

“the GPS protocol, which is GLP-1 protein strength training. They have to go together.”

“everyone wants to know about like the sunken face or the flat butt. How do you prevent that on GLP-1? So we talked a little bit about that. ... you got to really make sure you're eating the protein. ... And you're, you're doing the strength training. Non-negotiable.”

“I was skeptical until. I started following Dr. Jenna Siwak and Dr. Rocio Salas-Whalen on social and looking at the medical research journal articles they were presenting and then pulling them myself and reading them myself and realizing, wait a minute, I am allowing my own bias to stand in the way of what is, what could be potentially best”

“We do in our clinic, and we manage nutrition and resistance training and lower dosing. Of these medications, it doesn't have to be very high doses.”

“If she's lost weight now and then two years later wants to get off the drug, like 70% of people do, she will, her fat mass will come right back, but her lean mass may never come back. That muscle and bone may be gone for good.”