Does lowering LDL-related lipoproteins (LDL-C or ApoB/LDL-P) meaningfully reduce cardiovascular disease and related outcomes risk for most people?

“there was a regression. They looked at each, you know, one millimole reduction. So regardless of the variant, same reduction. And in the drug trials, the statin trials, regardless of how the statins worked, Also, with surgeries like, I think it was a little bypass or things that reduce LDL through absorption.”

“If you lower LDL before you have a heart attack, it's very effective. If you have a heart attack and you lower LDL, it still has benefit. But once you have heart failure, there's no benefit to lowering LDL. And so the earlier you start, the better.”

“For a one millimole, which is 38.8 milligrams per deciliter of LDL, you get a 22% relative risk reduction.”

“It's linear, right. But absolute is the key, not percent. You got to look at the absolute LDL lowering.”

“how many more trials do you need to show that LDL, no matter how you lower it, results in a clinical benefit?”

“In the first year of treatment, you get half the benefit at best. It takes time for the lines to separate.”

“all of these regressions are independent of how you do it. The Mendelian randomization says we're going to lower it genetically. ... So again, it speaks to this idea that reinforces the causality of LDL, because independent of how it's lowered, you're getting the same effects.”

“everything else being equal, having your LDL lower is better, all things being equal to having it higher.”

“Whenever there's a discrepancy in one direction or another, the cardiovascular risk tracks with the particle number, not the cholesterol.”

“We don't wait for stroke and heart failure to treat hypertension. We don't wait for blindness and kidney disease to treat diabetes. So I don't know why LDL gets this Stepchild type of role when it comes to how we manage, but it is causal and we know that.”

“the data says that if you keep your LDL below 80 throughout your lifetime, You don't get heart disease.”

“We have this path in right now today, which is the mainstream, is that you wait till someone has significant plaque buildup or even a heart attack or a stroke, then you treat super aggressively to get the LDL down. But we know from genomics that if you have a low LDL throughout your whole lifetime, it prevents heart disease”

“LDL is a dementia risk factor.”

“even with those LDL effects, which, which, which are not favorable, LDL predicts cardio adverse cardiovascular endpoints. But I believe that.”

“studies show that lowering LDL cholesterol has a very minimal effect on reducing your risk of heart disease and stroke.”

“studies show that lowering LDL cholesterol has a very minimal effect on reducing your risk of heart disease and stroke. There may be some benefit to doing it for people that have already had heart disease and strokes”

“in 22 years in the mortality space, we didn't process a single death claim on a centenarian, someone over the age of 100, that did not have clinically elevated levels of LDL cholesterol at the time of their death.”

“if you had low triglycerides, 75 milligrams per deciliter or less, and you had high LDL cholesterol, we would extend your life expectancy.”

“all of these regressions are independent of how you do it. The Mendelian randomization says we're going to lower it genetically. ... So again, it speaks to this idea that reinforces the causality of LDL, because independent of how it's lowered, you're getting the same effects.”

“Whenever there's a discrepancy in one direction or another, the cardiovascular risk tracks with the particle number, not the cholesterol.”

“We don't wait for stroke and heart failure to treat hypertension. We don't wait for blindness and kidney disease to treat diabetes. So I don't know why LDL gets this Stepchild type of role when it comes to how we manage, but it is causal and we know that.”

“even with those LDL effects, which, which, which are not favorable, LDL predicts cardio adverse cardiovascular endpoints. But I believe that.”

“everything else being equal, having your LDL lower is better, all things being equal to having it higher.”

“there was a regression. They looked at each, you know, one millimole reduction. So regardless of the variant, same reduction. And in the drug trials, the statin trials, regardless of how the statins worked, Also, with surgeries like, I think it was a little bypass or things that reduce LDL through absorption.”

“We have this path in right now today, which is the mainstream, is that you wait till someone has significant plaque buildup or even a heart attack or a stroke, then you treat super aggressively to get the LDL down. But we know from genomics that if you have a low LDL throughout your whole lifetime, it prevents heart disease”

“It's linear, right. But absolute is the key, not percent. You got to look at the absolute LDL lowering.”

“how many more trials do you need to show that LDL, no matter how you lower it, results in a clinical benefit?”

“the data says that if you keep your LDL below 80 throughout your lifetime, You don't get heart disease.”

“if you had low triglycerides, 75 milligrams per deciliter or less, and you had high LDL cholesterol, we would extend your life expectancy.”